3-d cell modeling and investigating its movement on non-rigid substrates
نویسندگان
چکیده
introduction: attachment of blood and tissue cells to the extracellular matrix (ecm) is done with the help of specific joints, which are made between cells’ receptors and matrixes’ ligands. this interaction is vital for many biological activities such as cell migration, cancer development, and wound healing. the purpose of this study is to model a 3-dimensional cell by abaqus commercial software package and investigate effects of factors, including mechanical properties of focal adhesion, substrate stiffness and cell active stress on cell motility over a smooth non-rigid substrate. methods: in our model, the cell is assumed to be a continuum and continuum mechanics equations are used for the cell, also due to symmetry in the geometry of the problem, symmetric approach has been applied in order to conserve timep. results: simulation results of this modeling demonstrate that mechanical properties of focal adhesion between cell and substrate and also substrate stiffness have considerable effect on cell motility. conclusion: in fact, increase in substrate stiffness and also increase in focal adhesion strength cause an increase in magnitude of cell-substrate traction stress and on the other hand, increase in these two parameters causes cell motility velocity to continue its decreasing trend. furthermore, magnitude of traction stress and cell movement speed highly depends on the active stress in the cell which perceptible increase can be observed in these two values when active stress increases. these results agree with experimental data reported by other authors.
منابع مشابه
Modeling crawling cell movement on soft engineered substrates.
Self-propelled motion, emerging spontaneously or in response to external cues, is a hallmark of living organisms. Systems of self-propelled synthetic particles are also relevant for multiple applications, from targeted drug delivery to the design of self-healing materials. Self-propulsion relies on the force transfer to the surrounding. While self-propelled swimming in the bulk of liquids is fa...
متن کاملContractile cell forces exerted on rigid substrates.
Adhesive cells including fibroblasts produce contractile forces to the underlying substrate for their locomotion. Such forces are not only high enough to deform compliant membranes such as silicone but also bend rigid micro-cantilevers. The cell-induced bending of silicon micro-cantilevers was determined using laser deflection during trypsin treatment. The observed cantilever relaxation corresp...
متن کاملSHREC ’ 15 Track : Non - rigid 3 D Shape Retrieval †
Non-rigid 3D shape retrieval has become a research hotpot in communities of computer graphics, computer vision, pattern recognition, etc. In this paper, we present the results of the SHREC’15 Track: Non-rigid 3D Shape Retrieval. The aim of this track is to provide a fair and effective platform to evaluate and compare the performance of current non-rigid 3D shape retrieval methods developed by d...
متن کاملMatching 3-D Anatomical Surfaces with Non-Rigid Volumetric Deformations
This paper presents a new method for determining the minimal non-rigid deformation between two 3-D surfaces, such as those which describe anatomical structures in 3-D medical images. Although we match surfaces, we represent the deformation as a volumetric transformation. Our method performs a least squares minimization of the distance between the two surfaces of interest. To quickly and accurat...
متن کاملGeometric Modeling of Dubins Airplane Movement and its Metric
The time-optimal trajectory for an airplane from some starting point to some final point is studied by many authors. Here, we consider the extension of robot planer motion of Dubins model in three dimensional spaces. In this model, the system has independent bounded control over both the altitude velocity and the turning rate of airplane movement in a non-obstacle space. Here, in this paper a g...
متن کاملComprehensive 3-D Notching Simulator With Non-Planar Substrates
A comprehensive three-dimensional simulation model for non-planar substrate lithography is presented. Matching substrate as well as standing wave effects are examined. The projection printing is simulated using Hopkins' results and the exposure model is solved using spectral element discretizations of the nonlinear wave equation coupled with the rate equation for the photoactive compound concen...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
مجله پزشکی مولکولیجلد ۱، شماره ۱، صفحات ۱۳-۱۹
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023